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The true extent of the synthetic opioid epidemic is likely underestimated because of these compounds not being included in routine drug monitoring (1). Opioid Types Semi-Synthetic Opioids: Drugs that are not naturally occurring substances and are not opiates. These drugs have similar. Natural and Semisynthetic Opioids (e.g. oxycodone, hydrocodone). Synthetic Opioids, other than Methadone (e.g. fentanyl, tramadol). Methadone. Heroin.

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Fentanyl is a powerful synthetic opioid that is similar to morphine but is 50 to times more potent. It is a prescription drug that is also made. This infographic summarizes a study that finds that nearly half of opioid-related overdose deaths involve fentanyl. There are also products that work by binding to the same receptors as opiates, but do not occur naturally, known as semi-synthetic or synthetic.

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